Insulin-Like Growth Factor 1 in the Preterm Rabbit Pup: Characterization of Cerebrovascular Maturation following Administration of Recombinant Human Insulin-Like Growth Factor 1/Insulin-Like Growth Factor 1-Binding Protein 3.

Dev Neurosci · 2021 · PMC8623584 · PMID 34218224

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showed a trendno p-value reported

A recent phase 2 clinical study of rhIGF-1/rhIGFBP-3 treatment showed a trend toward decreased occurrence of severe IVH as compared to standard neonatal care [ 16 ].

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a clear trendno p-value reported

To a large extent, data from specific qPCR analysis confirmed the profiler array data, particularly showing that the most significant effect of rhIGF-1/rhIGFBP-3 was present at 24 h after the first dosing, that is, a significant upregulation of ANGPT1, IGF-1, and COL1A1 and a clear trend to upregulation of FN1 and VCAN as compared to vehicle-treated animals.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.