Genetic factors affecting dopaminergic deterioration during the premotor stage of Parkinson disease.

NPJ Parkinsons Dis · 2021 · PMC8626486 · PMID 34836969

Europe PMC DOI

hedged sentences

0.0520

closest p · 1.0× alpha

0.0870

boldest claim

The sentences

showed a trendp = 0.052so close (0.05 < p ≤ 0.1)

However, GRSs showed a trend for correlation with a smaller annual change of putaminal SBRs (LMM, estimate = 0.012, SE 0.006, p = 0.052).

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did not reach statistical significancep = 0.087so close (0.05 < p ≤ 0.1)

Comparison between EOPD and LOPD In the linear mixed effects model (LMM) test with the interaction term, AAO was associated with lower annual change rates (faster decline), however, it did not reach statistical significance (estimate of AAO −0.0012, SE 0.0007, p = 0.087; Supplementary Table 1 ).

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