Histone variant H2A.Z regulates zygotic genome activation.

3g , mean hatching rate 2.22% compared to 91.15% in Ctrl embryos) and also showed a trend towards transcriptional downregulation of H2A.Z positive genes at ZGA, though not as strong as for the DomKD background (Supplementary Fig. 3h ).

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We observed that H2A.Z-positive genes are associated with basic cellular processes such as cell cycle and RNA metabolism, whereas both H2A.Z-negative and Zld-dependent genes show a strong trend towards developmental specific functions such as neuron differentiation or tissue morphogenesis.

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