A Novel Prognostic Biomarker Panel for Early-Stage Colon Carcinoma.

Cancers (Basel) · 2021 · PMC8656725 · PMID 34885019

Europe PMC DOI

hedged sentences

0.0610

closest p · 1.2× alpha

0.0700

boldest claim

The sentences

tendency toward significancep = 0.061so close (0.05 < p ≤ 0.1)

Adding the loss of expression of CDX2 to the multivariate model showed it to have a tendency toward significance as increased risk of death (HR = 2.74, 95% CI (0.96–7.84), p = 0.061), and it was statistically significant for risk of death or relapse (HR = 2.77, 95% CI (1.06–7.23), p = 0.037). 3.2.

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near statistical significancep = 0.070so close (0.05 < p ≤ 0.1)

CDX2 was near statistical significance for DFS (HR = 2.15, 95% CI (0.92–5.04), p = 0.070).

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showed a trendno p-value reported

Despite the very small number of events, CDX2 showed a trend toward statistical significance for worse prognosis; thus, an exploratory sensitivity analysis was conducted.

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