Stage I-IV Colorectal Cancer Prognosis Can Be Predicted by Type and Number of Intratumoral Macrophages and CLEVER-1<sup>+</sup> Vessel Density.

Cancers (Basel) · 2021 · PMC8656733 · PMID 34885098

Europe PMC DOI

hedged sentences

0.0550

closest p · 1.1× alpha

0.1200

boldest claim

The sentences

did not reach statistical significancep = 0.055so close (0.05 < p ≤ 0.1)

In stage IV metastatic disease a high CLEVER-1 + macrophage number was associated with numerically shorter DSS, although this finding did not reach statistical significance either [high 1.4 (95% CI: 0.9–2.2) years vs. others 4.6 (95% CI: 1.4–7.4) years, log-rank p = 0.055]. 3.3.

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failed to reach statistical significancep = 0.12not close (p > 0.1)

The present results, regarding CD68 + TAMs in stage I disease, were consistent with previous data, although they failed to reach statistical significance ( p = 0.12).

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borderline significantno p-value reported

In stage IV disease, a high intratumoral CLEVER-1 + macrophage number was associated with a numerically shorter DSS, although the finding was only borderline significant.

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