Integration of Tumor Heterogeneity for Recurrence Prediction in Patients with Esophageal Squamous Cell Cancer.

An ESCC-associated gene, ADAM29 [ 8 ], was mutated in an exclusively subclonal manner (8/8), including a mutational hotspot, 4 ADAM29 p.Q805 frame shift deletion, although this observation did not reach statistical significance ( Figure 1 B, p = 0.11).

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When we focused on hotspot mutations, we found that patients with the hotspot mutation TP53 R141C (7/201) appeared to have unfavorable DFS (HR: 2.58 (0.97–5.77), p = 0.06), but this observation failed to reach statistical significance probably because of the limited sample size ( Figure 1 F).

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