Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9.

As expected, we observed a strong trend toward reduced hepatic triglyceride levels in the HFD-fed Pde9a −/− mice ( Fig. 5 I ), with minor differences in fatty acid composition between genotypes ( Supplementary Table 3 ).

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Plasma triglyceride levels were unchanged and cholesterol showed a trend toward being reduced in HFD-fed Pde9a −/− mice ( Supplementary Fig. 6 ).

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