A Positively Selected MAGEE2 LoF Allele Is Associated with Sexual Dimorphism in Human Brain Size and Shows Similar Phenotypes in Magee2 Null Mice.

Mol Biol Evol · 2021 · PMC8662591 · PMID 34464968

Europe PMC DOI

hedged sentences

0.0670

closest p · 1.3× alpha

0.0670

boldest claim

The sentences

near-significantP = 0.067so close (0.05 < p ≤ 0.1)

However, a larger section of the human brain containing posterior regions adjacent to the hippocampus (including the granular retrosplenial cortex) defined as the posterior temporal lobe, was one of the human brain regions, whose volume was significantly associated with rs1343879 genotype (lPosTeLo P = 0.017 in the combined sample, the genotype by sex interaction was near-significant FDR P = 0.067; supplementary file 2 , Supplementary Material online).

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did not reach statistical significanceno p-value reported

The brain size in homozygous females showed the opposite trend of reduced brain size, although this did not reach statistical significance.

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