Genetic variants in the p53 pathway influence implantation and pregnancy maintenance in IVF treatments using donor oocytes.

A negative trend for homozygous Pro72 recipients was observed by decreased implantation and clinical pregnancy rates (Table 4 ).

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However, it is very interesting that the homozygous genotype A/A, which represents the lowest frequency not only among the studied population but also in the wide European people (1000 Genomes) [ 32 ], significantly increased in the group of recipient β-hCG ( +) (Table 3 ) and also presented with a trend to higher IR compared to the genotypes A/G and G/G, although this comparison did not reach statistical significance (Table 4 ).

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