Barely Significant
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A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues.

J Biol Chem · 2022 · PMC8689209 · PMID 34801552

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GIRKO mice had a trend for increased ad libitum blood glucose and insulin on day 0, which did not reach statistical significance ( Fig. 4 , A and B ).

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However, the other trabecular parameters (BV/TV, Tb.Th, BMC) and the cortical parameters (BMD, Cort.Th, bending and torsional moments, bone tissue areas) failed to reach statistical significance when comparing GIRKO to controls.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.