GIRKO mice had a trend for increased ad libitum blood glucose and insulin on day 0, which did not reach statistical significance ( Fig. 4 , A and B ).
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A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues.
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However, the other trabecular parameters (BV/TV, Tb.Th, BMC) and the cortical parameters (BMD, Cort.Th, bending and torsional moments, bone tissue areas) failed to reach statistical significance when comparing GIRKO to controls.