The position of single-base deletions in the VNTR sequence of the carboxyl ester lipase (CEL) gene determines proteotoxicity.

J Biol Chem · 2021 · PMC8692231 · PMID 33862081

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of borderline significanceno p-value reported

For DEL1, we also observed increased levels of borderline significance for GRP78 and ATF3 (1.5-fold and 1.3-fold, respectively).

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did not quite reach statistical significanceno p-value reported

For DEL4, we observed a 2- to 10-fold increase in expression of the same ER stress markers although the differences did not quite reach statistical significance because of large experimental variation ( Fig. 6 B ).

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a clear trendno p-value reported

There was a clear trend for DEL1 and DEL4 to upregulate ER stress markers, both when compared with WT and with the distal DEL variants DEL9 and DEL13.

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did not reach statistical significanceno p-value reported

TRUNC exhibited a 2.5-fold reduction that did not reach statistical significance because of large experimental variation.

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