Adverse Outcome in COVID-19 Is Associated With an Aggravating Hypo-Responsive Platelet Phenotype.

Further, patients with fatal outcome showed a trend toward increased CD40L and CD63 expression and GPIIb/IIIa activation compared to those with non-fatal outcome, indicating augmented platelet degranulation and fibrinogen binding capacity ( Figure 1B and Supplementary Figure 2A ).

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Though data did not reach statistical significance ( Figure 1C and Supplementary Figure 2B , data not shown), they suggest that fatal COVID-19 outcome is associated with hyper-active but hypo-reactive platelets.

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