Plasma amino acid profiling improves predictive accuracy of adverse events in patients with heart failure.

In a post hoc analysis using a validation cohort ( Detailed Methods in supporting information ), associations of high 3‐Me‐His and low valine, but not low β‐alanine, with lower event‐free survival rate was observed ( Figure S3D–F ), although the difference did not reach statistical significance presumably due to the small sample size ( n = 53).

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When male and female patients were combined after subdivision into ASMI tertiles within sex to avoid sex differences in ASMI, there was a significant trend for lower log 3‐Me‐His in higher tertile of ASMI ( Figure 5 F ).

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