Reduced CCR5 Expression and Immune Quiescence in Black South African HIV-1 Controllers.

Front Immunol · 2021 · PMC8720782 · PMID 34987508

Europe PMC DOI

hedged sentences

0.0090

closest p · 0.2× alpha

0.0930

boldest claim

The sentences

highly significantP =0.009actually significant

However, when groups were matched for both CCR5 promoter haplotype and age (n=6 for both) reduced CCR5 density on monocytes in controllers relative to HCs was highly significant ( P =0.009).

also in 132,142 other papers

a strong trendP =0.07so close (0.05 < p ≤ 0.1)

However, controllers had a strong trend of higher proportions of CCR5-expressing CD8+ T cells in comparison to HCs ( P =0.07, Figure 1D ).

also in 5,725 other papers

showed a trendP= 0.071so close (0.05 < p ≤ 0.1)

IL-12 was the only cytokine that showed a trend of higher PHA-induced production in controllers relative to the HCs ( P= 0.071, Figure 5E ).

also in 53,322 other papers

a weak trendP =0.093so close (0.05 < p ≤ 0.1)

The significant difference in CD4+ T cell CCR5 density was lost when CCR5 genotype-matched subgroups were compared; however, a weak trend was maintained ( P =0.093, Supplementary Table 4 ).

also in 1,404 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.