Facilitation of colonic T cell immune responses is associated with an exacerbation of dextran sodium sulfate-induced colitis in mice lacking microsomal prostaglandin E synthase-1.

DSS treatment resulted in a decrease in the colonic mRNA expression level of the tight junction molecules occludin and claudin-1, which play crucial roles in regulating intestinal paracellular permeability [ 40 ], but the differences in the expression levels of these molecules between WT and mPGES-1 −/− mice did not reach statistical significance in this study (Fig. 2 D). mPGES-1 −/− mice display anemia and extramedullary hematopoiesis in spleen mPGES-1 −/− mice exhibited marked splenomegaly by day 7 after the start of DSS administration, as shown in Fig. 3 A.

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Uptake of DSS-containing water did not differ between WT and mPGES-1 −/− mice, although the latter showed a trend towards consuming less water ( Fig.

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