Except for the decrease in the phosphorylation level of AKT (just over the limits of statistical significance, p = 0.055) and 4EBP1 at HU1, no significant changes in the phosphorylation levels of AKT, mTOR, and 4EBP1 were found during disuse.
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Exercise Preconditioning Blunts Early Atrogenes Expression and Atrophy in Gastrocnemius Muscle of Hindlimb Unloaded Mice.
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The expression of almost all atrogenes was lower 1 day after HU preceded by preconditioning (EX7 + HU1) than at HU1 with the only exception of MUSA1 , Mt1 , and TGIF whose reduced expression did not reach statistical significance ( Figure 3 ).