ONLINE-TICS: Internet-Delivered Behavioral Treatment for Patients with Chronic Tic Disorders.

J Clin Med · 2022 · PMC8745756 · PMID 35011989

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.1800

boldest claim

The sentences

a clear trendp = 0.053so close (0.05 < p ≤ 0.1)

Using a linear mixed model with the change to baseline of Yale Global Tic Severity Scale-Total Tic Score (YGTSS-TTS) as a dependent variable, we found a clear trend towards significance for superiority of iCBIT ( n = 67) over placebo ( n = 70) (−1.28 (−2.58; 0.01); p = 0.053).

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a trend towards significancep = 0.072so close (0.05 < p ≤ 0.1)

In addition, we observed a significant difference between iCBIT and placebo in tic reduction as assessed by MRVS at V4 (−1.40 (−2.40; −0.40), p = 0.006), a trend towards significance at V3 (−0.88 (−1.84; 0.08), p = 0.072), but no difference at V5 (−0.87 (−1.95; 0.22), p = 0.117).

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did not reach statistical significancep = 0.180not close (p > 0.1)

Efficacy of f2f CBIT Compared to Placebo Although the greatest tic reduction according to YGTSS-TTS was found after f2f CBIT, the difference between f2f CBIT and placebo did not reach statistical significance (1.26 (−0.59; 3.1) p = 0.180) at V3.

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narrowly missed statistical significanceno p-value reported

Efficacy of iCBIT Compared to f2f CBIT Since our primary endpoint narrowly missed statistical significance, the key secondary analysis was tested in an exploratory instead of a confirmatory way.

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