Weight Change and the Association with Adherence and Persistence to Diabetes Therapy: A Narrative Review.

Assessment of the association between index date adherence and weight change by SEM (adjusted for drug and baseline characteristics) demonstrated a trend for adherent subjects to be more likely to lose weight compared with non-adherent subjects (OR 1.56, 95% CI 0.97, 2.49), but this trend did not reach statistical significance (p = 0.06). 40 Medication Adherence According to Categorical Weight Change Figure 2 shows the main findings from the prospective survey-based study by Grandy et al (2013), 39 in which adherence was reported according to categorical weight change associated with T2D medications grouped by known weight effect (gain or loss).

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Similarly, study participants who lost weight and received a GLP-1 RA or metformin had lower MMAS scores compared with individuals who gained weight while receiving these medications, but the difference failed to reach statistical significance. 39 Studies Associated with Discontinuation Overview of Discontinuation Studies The three studies reporting on discontinuation and weight were conducted in the USA (n = 2) and Israel (n = 1), and all were retrospective cohort studies using EMR data. 43–45 Discontinuation was measured by a prolonged gap in therapy, the duration of which varied by study ( Table 2 ).

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