Oxidative Stress Biomarkers and Mitochondrial DNA Copy Number Associated with <i>APOE4</i> Allele and Cholinesterase Inhibitor Therapy in Patients with Alzheimer's Disease.

A significant trend of lower mtDNA copy number was correlated with presence of the APOE4 allele in the AD cohort ( Figure 1 C, Ptrend < 0.001); however, this trend did not reach statistical significance in the non-AD cohort ( Figure 1 C, Ptrend = 0.053). 3.3.

also in 111,027 other papers

A significant trend was noted in the TBARS levels of both AD and non-AD cohorts, highest in the homozygous two alleles (1.86 and 1.80 μmol/L), followed by heterozygous one allele (1.70 and 1.74 μmol/L), and lowest in the no APOE4 allele (1.56 and 1.48 μmol/L).

also in 9,775 other papers