A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome.

E/A ratio measured in adult animals did not reach statistical significance difference in the model nor with the compound ( S1 Fig ).

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In aged animals, SAR247799 significantly reduced heart weight/tibia length ( Fig 3A ) , right atrial weight/tibia length ( Fig 3C ) , inter-ventricular septum at end-systole (IVSs) ( Fig 3E ) and LVPWs ( Fig 3G ) and showed a trend to reduce left atrial weight/tibia length ( Fig 3B ) , IVSd ( Fig 3D ) and LVPWd ( Fig 3F ) .

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