The dominant TP53 hotspot mutation in <b><i>IDH</i></b> -mutant astrocytoma, R273C, has distinctive pathologic features and sex-specific prognostic implications.

In addition, the Ki67 proliferation index for p53 R273C -mutant tumors in female patients tended to be lower compared to cases lacking this mutation, grade for grade ( Supplementary Figure S1E ), though this did not reach statistical significance ( P > .05, Mann–Whitney U-test).

also in 111,027 other papers

Additionally, TP53 R273C approached significance in multivariate Cox-PH analyses for both PFS ( P = .06–.08) and OS ( P = .13–.23) with a hazard ratio of 1.63-2.59 (UPMC cohort; Supplementary Table 2 ).

also in 8,237 other papers

22 Across cancers, each of these hotspot codons accounts for approximately 3–7% of the total point mutations; although 3–7% is far lower than the prevalence of single hotspot mutations in certain known oncogenes (eg BRAF V600E ), this degree of enrichment is nonetheless highly significant, and mutations at these codons are frequently hypothesized to confer beneficial gain-of-function (GOF) properties. 22 , 38 , 39 Given this baseline pan-cancer level of hotspot mutational frequencies, it is remarkable that in IDHmut astrocytomas the R273C amino acid change accounts for 20–30%+ of all TP53 mutations.

also in 132,142 other papers