Nos2^-/- mice infected with M. tuberculosis develop neurobehavioral changes and immunopathology mimicking human central nervous system tuberculosis.

Although the mycobacterial load in the brain of H37Rv-infected mice had a trend to increase compared to CDC1551-infected mice, this did not reach statistical significance.

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Concentrations of Th1-associated inflammatory mediators TNF-α and CXCL-10 were significantly higher in infected Nos2 −/− mice than infected C3HeB/FeJ mice, while IFN-γ and CCL-5 showed a trend to increase (Fig. 2 a–d).

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