Early Growth Response 1 Suppresses Macrophage Phagocytosis by Inhibiting NRF2 Activation Through Upregulation of Autophagy During <i>Pseudomonas aeruginosa</i> Infection.

Similarly, we found that pretreatment of autophagy activator RAP significantly reduced the phagocytic activity of RAW264.7 cells compared to untreated cells, whereas the autophagy inhibitor CQ-pretreated RAW264.7 cells showed a trend of increase in phagocytosis but did not reach statistical significance compared to untreated cells during of P. aeruginosa infections ( Figure 2A ).

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