Presynaptic mechanisms underlying GABA<sub>B</sub>-receptor-mediated inhibition of spontaneous neurotransmitter release.

Cell Rep · 2022 · PMC8793855 · PMID 35045279

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failed to reach statistical significanceno p-value reported

ct-GRK2 expression resulted in mild attenuation of baclofen’s inhibitory effect on mEPSC frequency, albeit failed to reach statistical significance ( Figure 1E ).

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showed a trendno p-value reported

Nevertheless, expression of soluble ct-GRK2 showed a trend toward attenuation of baclofen-induced inhibition of spontaneous release, which became more robust and statistically significant upon myristoylation that anchors ct-GRK2 to the membrane.

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