Benefits of intraoral stents for sparing normal tissue in radiotherapy of nasopharyngeal carcinoma: a radiobiological model-based quantitative analysis.

As shown for NTCP, complication probability of oral cavity (P<0.001) was significantly decreased in patients with intraoral stent, and there was also a strong trend toward a decrease in parotids (P<0.001).

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In agreement with previous work, dosimetric analysis of this study showed that patients who wore the intraoral stent had a decreasing trend in radiation dose to adjacent normal tissue, especially for oral cavity, mandible and bilateral parotid, which may be due to the intraoral stent increased distance between the mandible and the maxilla.

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The D mean of bilateral TMJ and submandibular glad was slightly lower in patients with intraoral stent, although it did not reach statistical significance ( Table 5 , Figure 3 ).

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