Iron Deficiency in Inflammatory Bowel Disease Is Associated With Low Levels of Vitamin D Modulating Serum Hepcidin and Intestinal Ceruloplasmin Expression.

Clin Transl Gastroenterol · 2022 · PMC8806373 · PMID 35029158

Europe PMC DOI

hedged sentences

0.0050

closest p · 0.1× alpha

0.0550

boldest claim

The sentences

highly significantP = 0.005actually significant

The 1,25(OH)D:25(OH)D ratio showed a highly significant inverse correlation with serum hepcidin concentrations in patients with IBD (Kendall τ 0.19, P = 0.005; Figure 4 a).

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a clear trendP = 0.054so close (0.05 < p ≤ 0.1)

Furthermore, we identified a clear trend toward an inverse association of serum 25(OH)D levels with iron deficiency anemia (β [SE] = −0.385 [0.199], P = 0.054) and anemia in general (β [SE] = −0.364 [0.200], P = 0.069) in patients with IBD.

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almost significantP = 0.055so close (0.05 < p ≤ 0.1)

Taking into account the entire IBD population, the result was almost significant (β [SE] = 0.258 [0.131], P = 0.055).

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a statistical trendno p-value reported

Despite a statistical trend, hemoglobin levels and diagnosis of anemia were not significantly influenced by vitamin D status in our cohort of adult patients with IBD.

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showed a trendno p-value reported

Serum iron (β [SE] = 0.180 [0.096], P = 0.065) showed a trend toward a positive multivariate association with vitamin D sufficiency.

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