Pharmacological disruption of the MTDH-SND1 complex enhances tumor antigen presentation and synergizes with anti-PD-1 therapy in metastatic breast cancer.

Although interferon related signatures showed a trend to be enriched in MTDH KO tumorspheres, the overall enrichment scores are much lower as compared to that from in vivo tumor samples ( Extended Data Fig. 1h ), indicating that the enriched interferon-related signatures are mostly caused by changes in the tumor microenvironment.

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Of note, although we observed increased trend of metastasis in control groups upon CD8 + T depletion, the difference did not reach statistical significance, and the increase was much lower as compared to MTDH KD groups ( Extended Data Fig. 2d ).

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