Mucosal Gene Transcript Signatures in Treatment Naïve Inflammatory Bowel Disease: A Comparative Analysis of Disease to Symptomatic and Healthy Controls in the European IBD-Character Cohort.

Clin Exp Gastroenterol · 2022 · PMC8848803 · PMID 35185343

Europe PMC DOI

hedged sentences

0.0450

closest p · 0.9× alpha

0.0450

boldest claim

The sentences

nominally significantp = 0.045actually significant

IGFBP1 expression was found to be nominally significant in inflamed UC samples (p = 0.045), possibly predicting treatment escalation.

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did not reach statistical significanceno p-value reported

We find it interesting that expression of transcripts involved in mitochondrial functions and barrier functions are dominating the clustering, even though the comparison of the signatures regarding their inclination to treatment escalation did not reach statistical significance.

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