ACSS3 in brown fat drives propionate catabolism and its deficiency leads to autophagy and systemic metabolic dysfunction.

Clin Transl Med · 2022 · PMC8858619 · PMID 35184387

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showed a trendno p-value reported

Carbon dioxide (CO 2 ) production of Acss3 –/– mice also showed a trend to increase, but did not reach a significant level (Figure 3H, I ).

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a negative trendno p-value reported

a positive trendno p-value reported

These results establish a negative trend of ACSS3 expression level, along with a positive trend of propionate accumulation, with obesity and T2D in humans. 3.6.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.