Serum glial fibrillary acidic protein as a biomarker of brain injury in premature neonates.

Finally, the multivariable logistic regression analysis including as independent variables serum GFAP and S100B levels during the first 3 days of life confirmed that the predictive value of serum GFAP, regarding either the development of NBI or a severe adverse neonatal outcome such as II-IV grade IVH complicated by seizures/hypertonia or death, is limited, as it did not reach statistical significance (results not shown).

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Nevertheless, as in the study by Stewart et al., we identified a clear trend as GFAP was detected more frequently below the lowest detection limit (0.056 ng/ml) in the control group compared to neonates with NBI.

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