Study Design Characteristics and Endpoints for Enriched Enrollment Randomized Withdrawal Trials for Chronic Pain Patients: A Systematic Review.

J Pain Res · 2022 · PMC8860756 · PMID 35210848

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did not reach statistical significanceno p-value reported

33 , 34 Two out of the 19 EERW chronic pain trials using the NRS or VAS did not reach statistical significance between groups. 22 , 24 Most of the trials calculated the number of patients needed with a power of 90%; other trials used 80%, 27 , 33 88%, 20 and 99%. 31 The mean effect size on the NRS used in the power calculation of the 18 trials was 0.89 (SD: 0.47, range: 0.3 to 2).

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failed to reach statistical significanceno p-value reported

While this observation failed to reach statistical significance at the traditional 0.05 threshold, it is important to note that the threshold is arbitrary.

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