Effects of hyperinsulinemia on pancreatic cancer development and the immune microenvironment revealed through single-cell transcriptomics.

Cancer Metab · 2022 · PMC8862319 · PMID 35189981

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did not reach statistical significanceno p-value reported

Although the pairwise comparison between genotypes did not reach statistical significance in the present study [ 19 ], our findings still support a role for hyperinsulinemia promoting PanIN initiation from acinar cells sustaining mutations in the oncogene Kras .

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a clear trendno p-value reported

At this age, PK- Ins1 -/- ; Ins2 +/+ and PK- Ins1 -/- ; Ins2 +/- male mice secreted similar levels of insulin in response to intraperitoneal delivery of glucose; in females, we noted a clear trend in PK- Ins1 -/- ; Ins2 +/- mice towards reduced glucose-stimulated insulin secretion (Fig. 1 I–J).

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