Circulating LIGHT (TNFSF14) and Interleukin-18 Levels in Sepsis-Induced Multi-Organ Injuries.

Biomedicines · 2022 · PMC8869623 · PMID 35203474

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0630

boldest claim

The sentences

showed a trendp = 0.060so close (0.05 < p ≤ 0.1)

Patients with viral sepsis showed a trend of having lower LIGHT levels than patients with bacterial sepsis, albeit not statistically different ( p = 0.060).

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borderline significancep = 0.063so close (0.05 < p ≤ 0.1)

Borderline significance was seen between increased length of ICU/hospital stay (LOS) and elevated LIGHT ( r = 0.196, p = 0.063).

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highly significantno p-value reported

Overall, IL-18 levels were correlated with Apache III scores, mortality, and AKI, with highly significant p -values, and correlated with AHRF and ARDS with nominal significance.

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a significant trendno p-value reported

The detrimental roles of LIGHT in multi-organ failure were mainly seen in bacterial sepsis, including ARDS/AHRF, AKI, and its association with higher Apache III score, as well as length of hospital stay, with a significant trend toward higher mortality rates.

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