MiR-30 promotes fatty acid beta-oxidation and endothelial cell dysfunction and is a circulating biomarker of coronary microvascular dysfunction in pre-clinical models of diabetes.

FADS2, ELOVL5, FASN ) were increased at the mRNA level in unstimulated cells, and additional target genes were significantly elevated or showed a trend towards increased expression in palmitate-stimulated cells transfected with miR-30 inhibitor (Fig. 6 E; Additional File 1 : Fig.

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Transfection with a miR-30 family LNA inhibitor significantly decreased miR-30e levels by ~ 55–60%, but there was a more modest ~ 30% reduction in miR-30d, which did not reach statistical significance (Fig. 6 B).

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