Barely Significant
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Cytokine and Reward Circuitry Relationships in Treatment-Resistant Depression.

Biol Psychiatry Glob Open Sci · 2022 · PMC8889578 · PMID 35252950

Europe PMCDOI
2
hedged sentences
0.0890
closest p · 1.8× alpha
0.0890
boldest claim

The sentences

did not reach statistical significancep = .089so close (0.05 < p ≤ 0.1)
Post hoc simple slopes analysis of this interaction effect found that for individuals with higher trauma severity (i.e., +1 standard deviation), TNF-α was positively associated with right VS (RVS)-RBA11 connectivity ( B = 0.07, p = .03, n = 73), while negative associations of TNF-α with RVS-RBA11 connectivity for individuals with lower trauma severity (i.e., −1 standard deviation) did not reach statistical significance ( B = −0.07, p = .089, n = 73).

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near-significantno p-value reported
No significant trauma moderation effects were found for IL-6 and connectivity after multiple comparisons adjustment (adjusted p s > .05), although near-significant associations before multiple comparisons adjustment are described in Table S4 .

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