Lipidomic risk scores are independent of polygenic risk scores and can predict incidence of diabetes and cardiovascular disease in a large population cohort.

First, we observed only a very weak correlation between the lipidomic risk score and the time to first disease incidence ( Fig 2 ), in contrast to the predictive power of an alternative risk score based on standard clinical measurements, which showed a trend of decreasing values with increasing time to incidence ( S2 Fig ).

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This score showed a clear trend of increase with increasing T2D and CVD incidence rate.

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