Relationship between glucose homeostasis and obesity in early life-a study of Italian children and adolescents.

We performed the association analyses with FG, FI, HOMA-B, HOMA-IR and BMI SDS for the 42 variants, assuming an additive genetic model implemented in linear regression and detected nominally significant associations ( P < 0.05) at eight FG, eight T2D and two FI loci with the phenotypes tested (Material and Methods, Supplementary Material, Table S1 ).

also in 7,732 other papers

The unweighted GRS provided mostly similar but weaker associations than the weighted GRS ( Table 2 ), except for the unweighted FG GRS that showed a trend towards a negative association with FI levels (−0.024 [−0.050, 0.0029] ln(pmol/l), P = 0.082) and this was further strengthened (−0.028 [−0.055, −0.0016] ln(pmol/l), P = 0.038) when adding adjustment for family history of T1D and T2D.

also in 53,322 other papers