Interestingly, the AJCC-UICC 8th Edition N classification [ 14 ] failed to reach statistical significance in our analysis.
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Regional disease in head and neck cutaneous squamous cell carcinoma: the role of primary tumor characteristics and number of nodal metastases.
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The presence of PNI was significantly associated with worse OS (HR = 1.85, p = 0.05), whereas the site of origin, tumor differentiation, resection margins, and LVI did not reach statistical significance (Fig. 2 ).