Biomolecular and Genetic Prognostic Factors That Can Facilitate Fertility-Sparing Treatment (FST) Decision Making in Early Stage Endometrial Cancer (ES-EC): A Systematic Review.

FGFR2 mutations were also consistent with more aggressive disease and were more common in patients with more advanced stage III/IV, although this did not reach statistical significance [ 63 ].

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KRAS Although evidence is limited and occasionally conflicting, there is a clear trend in the literature showing that KRAS plays a role early in EC progression, especially when the disease originates from hyperplastic endometrium [ 99 ].

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