"MATH+" Multi-Modal Hospital Treatment Protocol for COVID-19 Infection: Clinical and Scientific Rationale.

The risk for decreased viral clearance with CST is overstated and the most frequently quoted article by Arabi et al reported that in patients that received greater than 7 days CST, there was a strong trend toward lower 90-day mortality (aOR: 0.51, 95% CI: 0.26 - 1.00; P = 0.05) and no impact on viral clearance (aOR: 0.94, 95% CI: 0.36 - 2.47; P = 0.90) [ 43 ].

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In the sub-group of patients with SOFA scores ≥ 3, the differences in ICU and hospital mortality were statistically significant while the 28-day mortality approached, but did not reach statistical significance (21.7% vs. 52.4%, P = 0.06) [ 81 ].

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