Evaluation of Melatonin Therapy in Patients with Myocardial Ischemia-Reperfusion Injury: A Systematic Review and Meta-Analysis.

Oxid Med Cell Longev · 2022 · PMC8913055 · PMID 35281465

Europe PMC DOI

hedged sentences

0.1600

closest p · 3.2× alpha

0.5800

boldest claim

The sentences

a strong trendP = 0.16not close (p > 0.1)

When melatonin was taken orally beforehand, there were no significant effects on LVEF, but there was a strong trend to promote LVEF (SMD: 0.60; 95% CI: −0.24 to 1.43; P = 0.16; and I 2 = 79.4%, Figure 4(b) ).

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showed a trendP = 0.58not close (p > 0.1)

The results suggested that melatonin intervention had no significant effects on LVEF, LVEDV, and LVESV compared to the control groups but showed a trend to enhance LVEF (SMD: 0.11; 95% CI: −0.29 to 0.52; P = 0.58; and I 2 = 78.4%), LVEDV (SMD: 0.13; 95% CI: −0.08 to 0.34; P = 0.22; and I 2 = 0%), and LVESV (SMD: 0.20; 95% CI: −0.03 to 0.43; P = 0.095; and I 2 = 18.1%) in Figure 3(a) .

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