Platelet-released extracellular vesicles: the effects of thrombin activation.

Platelet fraction showed a decreasing trend in PCDHA4 protein upon clopidogrel treatment, suggesting an agonist-dependent platelet aggregation impact on EV release and cargoes.

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Protein disulfide isomerase A3 (PDIA3) showed a trend to increase in T-pEVs (Fig. 4 ).

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Similarly, 10-top highly significant FunRich biological pathways were found in non-activated pEVs that were related to platelet function, coagulation system, thrombosis, and haemostasis proving the validity of the bioinformatics analyses (Supplementary Table 4).

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Western blot validation in pEVs confirmed its reduction upon thrombin stimulation, though the change did not reach statistical significance (Fig. 5 B).

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