<i>Bacillus</i> Calmette-Guérin Treatment Changes the Tumor Microenvironment of Non-Muscle-Invasive Bladder Cancer.

There was a trend of enrichment of APOBEC-mediated mutations in relapsed compared with primary tumors, although the difference did not reach statistical significance ( p = 0.29, Fisher’s exact test, Figure S6 ).

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Although none of 67 immune regulatory genes was significantly expressed ( Table S10 ) ( 23 ), some T-cell exhaustion genes showed a trend toward upregulation in the relapsed tumors ( Figure S13 ).

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