Conditional loss of IKKα in Osterix + cells has no effect on bone but leads to age-related loss of peripheral fat.

After 8–11 weeks on HFD, male cKO mice showed a trend towards better glucose tolerance, but this did not reach statistical significance in our cohorts (Fig S9 e).

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Although adiponectin and the lipolysis enzymes (hormone sensitive lipase and adipose triglyceride lipase) trended modestly downward at both ages in cKO compared to CON animals, they did not reach statistical significance (Fig S8 a, b).

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Insulin tolerance was not significantly different in either sex at this point, although female cKO showed a slight trend towards better tolerance (Figs. 8 c, d and S9 f.).

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