Metformin: A Narrative Review of Its Potential Benefits for Cardiovascular Disease, Cancer and Dementia.

Pharmaceuticals (Basel) · 2022 · PMC8951049 · PMID 35337110

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a decreasing trendno p-value reported

Although micro- and macrovascular events both had a decreasing trend in metformin users, statistical significance was not reached.

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

Three randomized trials of metformin use in non-small cell lung cancer (NSCLC) non-diabetic patients taken together did not reach statistical significance but showed a trend towards improved survival in the two meta-analyses (HR 0.86, 95% CI 0.68–1.08 and HR 0.73, 95% 0.47–1.15).

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