Comprehensive Characterization of Human Lung Large Cell Carcinoma Identifies Transcriptomic Signatures with Potential Implications in Response to Immunotherapy.

However, despite the reduced number of patients, the analysis suggested a clear trend towards a greater PFS and OS in the pro-immunogenic group, as might be expected.

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Interestingly, PSBM9 was not selected under our criteria but almost reached statistical significance in our study (FDR = 0.01 and log 2 Fold Change = 0.96, upregulated in the pro-immunogenic subgroup) which suggests that our biomarker filtering criteria could perhaps be reassessed in order to identify additional genes with potential as biomarkers.

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Tumors defined as pro-tumorigenic showed a trend to accumulate certain molecular aberrations and were found in a higher proportion of relapsed patients.

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