An exploratory pilot study on the involvement of APOE, HFE, C9ORF72 variants and comorbidities in neurocognitive and physical performance in a group of HIV-infected people.

Only the model built on CDT score showed a trend to significance (F (22, 31) = 1,52; p = 0.14), suggesting that CDT score could be positively associated with the APOEε3 allele (2,2; 95% CI [0,03 0,8]; p = 0.037).

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In our cohort we found that the APOEε2ε4 subjects had worse performances in all tests, even lower than subjects with the ε3ε4 genotype, although the differences did not reach statistical significance (Fig. 1 and Supplementary Table S6a).

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