A Model of Combined Exposure to Nicotine and Tetrahydrocannabinol <i>via</i> Electronic Cigarettes in Pregnant Rats.

Front Neurosci · 2022 · PMC8966542 · PMID 35368251

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hedged sentences

0.0100

closest p · 0.2× alpha

0.0700

boldest claim

The sentences

did not reach statistical significancep < 0.01actually significant

Although the Day*Time*THC interaction did not reach statistical significance, plasma nicotine levels of dams exposed to combined Nicotine + THC, but not nicotine alone, gradually increased throughout pregnancy ( F [3,33] = 4.99, p < 0.01).

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approached significancep = 0.07so close (0.05 < p ≤ 0.1)

Dams increased water intake throughout the vapor inhalation period (Day: F [3,132] = 23.17, p < 0.001); a 3-way interaction of Day*Nicotine*THC approached significance ( F [3,132] = 2.38, p = 0.07) and there was a main effect of THC ( F [1,44] = 4.63, p < 0.05).

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