The Association of New-Onset Acute Kidney Injury and Mortality in Critically Ill Patients With COVID-19 With Less Severe Clinical Conditions at Admission: A Moderation Analysis.

As shown in Table 1 , the characteristics that showed a significant trend across SOFA tertiles were mean blood pressure values ( P = 0.006), need of vasopressors for hemodynamic support ( P < 0.001), need for MV ( P < 0.001), the time from symptom onset to ICU admission ( P = 0.014), and treatment with tocilizumab ( P = 0.013).

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We also observed an increasing trend in the prevalence of sepsis ( P = 0.011), which reached nearly 30% in the highest tertile ( Table 1 ); accordingly, as shown in Table 2 , there was an increasing trend of serum CRP ( P = 0.035) and serum procalcitonin (0.012) at the time of ICU admission across SOFA tertiles.

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Although the percentage of patients who died by 28-day of follow-up increased from 28.6% in the lowest to 55.2% in the middle and was 43.2% in the highest SOFA tertile, this trend did not reach statistical significance ( P = 0.13).

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