FOXO1 Couples KGF and PI-3K/AKT Signaling to NKX2.1-Regulated Differentiation of Alveolar Epithelial Cells.

The expression levels of the other two FOXO family members, FOXO3 and FOXO4, did not change significantly over time in culture ( Figure 1 A,C,D), although FOXO3 showed a trend toward an increase in the early days in culture (D1 and D3).

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The trend towards FOXO3 upregulation at the early stage of AT2-AT1 cell differentiation (day one and three) and stabilization at the late stages of differentiation (day five and day eight) suggests FOXO3 may also be involved in early AEC differentiation, although this did not reach statistical significance.

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